講座人：香港大學(xué) 馮榮錦（Wing Kam Fung）教授 博士生導(dǎo)師

題目：Powerful Tests for Genomic Imprinting Effects for Qualitative and Quantitative Traits on the X Chromosome

時間：3月5日(周日）上午9:30-11:00

地點(diǎn)：理學(xué)院大會議室（學(xué)14-514）

內(nèi)容簡介：

Genomic imprinting is an epigenetic phenomenon that the expression of an allele copy depends on its parental origin. This mechanism has been found to play an important role in many diseases. Methods for detecting imprinting effects have been developed primarily for autosomal markers. However, no method is available in the literature to test for imprinting effects on the X chromosome. Therefore, it is necessary to suggest methods for detecting such imprinting effects. In this talk, the parental-asymmetry test on X the chromosome (XPAT) is first developed to test for imprinting for qualitative traits in the presence of association, based on family trios each with both parents and their affected daughter. Then, we propose 1-XPAT to tackle parent-daughter pairs, each with one parent and his/her affected daughter. By simultaneously considering family trios and parent-daughter pairs, C-XPAT is constructed to test for imprinting. Further, we generalize the proposed methods to accommodate complete (with both parents) and incomplete (with one parent) nuclear families having multiple daughters of which at least one is affected. The proposed methods are extended to investigate quantitative trait loci having imprinting effects. Simulations are conducted to assess the performance of the proposed methods under different settings. Simulation results demonstrate that the proposed methods control the size well, irrespective of the inbreeding coefficient in females being zero or nonzero. For practical use, the proposed methods are applied to analyze the rheumatoid arthritis data.

個人簡介：  

馮榮錦（Wing Kam Fung），男，香港大學(xué)講席教授、統(tǒng)計(jì)及精算學(xué)系博士生導(dǎo)師，國際統(tǒng)計(jì)計(jì)算協(xié)會（IASC）現(xiàn)任主席，國際著名期刊《Computational Statistics & Data Analysis》主編，資深遺傳統(tǒng)計(jì)學(xué)家。研究領(lǐng)域涉及統(tǒng)計(jì)診斷、縱向數(shù)據(jù)分析、DNA分析、法醫(yī)統(tǒng)計(jì)和遺傳流行病學(xué)等多個領(lǐng)域。在國際學(xué)術(shù)期刊公開發(fā)表170余篇，2008年在英國Wiley出版專著《Statistical DNA Forensics: Theory, Methods and Computation》。獲得中國自然科學(xué)基金海外杰出青年基金（遺傳證據(jù)因果分析研究）、香港大學(xué)杰出研究員、杰出校友等多項(xiàng)學(xué)術(shù)獎勵，也是美國科學(xué)促進(jìn)協(xié)會（AAAS）、國際數(shù)理統(tǒng)計(jì)學(xué)會（IMS）、美國統(tǒng)計(jì)協(xié)會（ASA）等的會士（Elected Fellow）。

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理學(xué)院    

2017年2月27日